01 October 2005
Mutation features of 215 polymerase proteins from different influenza A viruses
Guang Wu, Shaomin YanMed Sci Monit 2005; 11(10): BR367-372 :: ID: 430293
Abstract
Background:The aim of the present study is to analyze 215 polymerase proteins from different influenza A viruses in order to gain insight into their mutation features.Material/Methods:Using our computational mutation models to calculate differences between actual and predicted frequencies, the amino-acid pairs in a protein can be classified into randomly predictable or unpredictable portions. By comparing the percentages of both portions and the magnitudes of the differences among different proteins, we can determine which proteins have larger unpredictable portions and larger differences, and these proteins would be more sensitive to mutations according to our previous studies.Results:There are five features regarding polymerase acidic protein (PA), polymerase basic protein 1 (PB1), and polymerase basic protein 2 (PB2): (i) the PA proteins are more sensitive to mutations; (ii) the PA and PB1 proteins have experienced more mutations in the past; (iii) the PA and PB2 proteins have a larger potential for future mutations; (iv) the impact of mutations on polymerase proteins is to minimize the difference between the actual and predicted frequencies of amino-acid pairs, and (v) the avian PA proteins are more vulnerable to mutations than the human ones.Conclusions:This study provides probabilistic evidence on the current state, history, and future of different polymerase proteins from influenza A viruses towards mutation. Our analyses also highlight the mutation tendency over time and the species susceptibility.
Keywords: Viral Proteins - genetics, Mutation, Influenza A virus - genetics
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952