01 October 2004
Influence of preischemic short-term triiodothyronine administration on hemodynamic function and metabolism of reperfused isolated rat heart
Piotr Kazmierczak, Anna Polak, Mirosław MussurMed Sci Monit 2004; 10(10): BR381-387 :: ID: 11785
Abstract
Background:The “euthyroid sick syndrome” may intensify dysfunction of the heart during acute myocardial ischemia. The present research was undertaken to outline the effects of preischemic short-term triiodothyronine (T[sub]3[/sub]) administration on hemodynamic function and metabolism of the myocardium during reperfusion.Material/Methods: Thirty-six isolated working rat hearts were assigned to three experimental groups and a control group. The hearts were removed from the animals and perfused in the modified Langendorff model. They were subjected to 30 minutes of initial perfusion, 40 minutes of ischemia, and 15 minutes of reperfusion. The experimental groups received 10 extra minutes of T[sub]3[/sub] administration followed by initial perfusion (concentration of T[sub]3[/sub] was: group 1–5.4 pmol/l, group 2–27 pmol/l, and group 3–54 pmol/l). Control hearts received perfusate without T[sub]3[/sub]. We evaluated the postischemic recovery of left ventricular function (aortic pressures, heart rate, cardiac output), coronary flow, and oxygen consumption.Results: Progressive percentage of recovery of aortic systolic pressure, aortic mean pressure, and cardiac output with increasing concentration of T[sub]3[/sub] was observed. Cardiac output reached the best recovery in the group with the highest concentration of T[sub]3[/sub] (80.9±7.5%) and was significantly better in comparison with the control group and the other experimental groups. No significant differences in coronary flow and oxygen consumption were noted.Conclusions: Triiodothyronine administered before ischemia improves postischemic left ventricular function with no changes in oxygen consumption and coronary flow.
Keywords: Triiodothyronine - administration & dosage, Coronary Circulation - drug effects, Coronary Vessels - drug effects, Heart - physiology, Hemodynamics - drug effects, Myocardial Ischemia - metabolism, Myocardium - metabolism, Oxygen - metabolism, Oxygen Consumption - drug effects, Rats, Wistar, Reperfusion, Time Factors, Triiodothyronine - pharmacology
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
11 Mar 2024 : Clinical Research
Comparison of Effects of Sugammadex and Neostigmine on Postoperative Neuromuscular Blockade Recovery in Pat...Med Sci Monit In Press; DOI: 10.12659/MSM.942773
12 Mar 2024 : Clinical Research
Comparing Neuromuscular Blockade Measurement Between Upper Arm (TOF Cuff®) and Eyelid (TOF Scan®) Using Miv...Med Sci Monit In Press; DOI: 10.12659/MSM.943630
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952