01 February 2006
Matrix metalloproteinase inhibitor (ONO-4817) attenuates ischemia-reperfusion injury in rat lung
Takehiko Shimoyama, Noriyuki Tabuchi, Jihwa Chung, Takatoshi Koyama, Makoto SunamoriMed Sci Monit 2006; 12(2): BR51-56 :: ID: 445227
Abstract
Background: Ischemia-reperfusion injury of the lungs seems to be initiatedby the activation of alveolar macrophages, and mediated by matrix metalloproteinases (MMP)s, althoughtheir roles have not been fully elucidated. Therefore, we used a novel MMP inhibitor (ONO-4817) withhigh affinities for MMP-2 and MMP-9 to investigate the roles of MMPs in reperfusion injury of the lungs.Material/Methods: After 18 h of cold ischemia, isolated rat lungs were ventilated and reperfused. Lungswithout ischemia served as controls. Lungs were reperfused with fresh blood with or without the MMP inhibitorfor 120 min at 37 degrees C. Results: The oxygenation capacity of lungs after ischemia deteriorated progressivelyduring 120 min of reperfusion, but was preserved by the MMP inhibitor (p
Keywords: Antigens, CD11c - metabolism, Antigens, CD31 - metabolism, Lung - physiopathology, Lung Injury, Macrophages, Alveolar - pathology, Matrix Metalloproteinase Inhibitors, Neutrophils - pathology, Phenyl Ethers - pharmacology, Protease Inhibitors - pharmacology, Reactive Oxygen Species - metabolism, Reperfusion Injury - prevention & control
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952