15 September 2000
Bronchoalveolar Lavage Cellular Profiles in Lung Transplantation : the Effec tof Inhaled Corticosteroids
Helen Whitford, Bernadette Orsida, Tom Kotsimbos, Michael Pais, Chris Ward, Ling Zheng, Trevor Williams, E Haydn Walters, Greg SnellAnn Transplant 2000; 5(3): 31-37 :: ID: 497537
Abstract
Bronchiolitis Obliterans Syndrome (BOS) remains a major cause of long term morbidity and mortality in lung transplantation. and occurs despite significant immunosuppression. I>Jrway inflammation is thought to precede the development of BOS. Objectives: To examine the effect of inhaled corticosteroids on airway inflammation and the development of BOS in lung transplant recipients. Methods: 30 patients were recruited and randomised in a double blind fashion to receive either 750 Ilg Fluticasone propionate (FP) twice daily or an identical appearing placebo for 3 months. BALcell counts and differentials were performed at time 0 and after 3 months treatment. Lung function was assessed at each time point using spirometry. Results: 24 patients were felt to be stable and free from infection at both time points and thus included in the analysis. There was a significant reduction in total cell count in BAl fluid after treatment with 3 months FP compared to 3 months placebo, however no change in cell differentials nor lung function was found. Discussion: Despite a reduction in total cell numbers in BAl fluid, lung function was not altered over the 3 months of treatment. It may be that longer treatment is required to see an effect.
Keywords: Lung Transplantation, inhaledsteroids, Bronchoalveolar Lavage, cell differentials
In Press
20 Mar 2024 : Original article
Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single InstitutionAnn Transplant In Press; DOI: 10.12659/AOT.942252
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
02 Apr 2024 : Original article
Liver Transplantation from Brain-Dead Donors with Hepatitis B or C in South Korea: A 2014-2020 Korean Organ...Ann Transplant In Press; DOI: 10.12659/AOT.943588
02 Apr 2024 : Original article
Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...Ann Transplant In Press; DOI: 10.12659/AOT.943281
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860