01 December 2007
Association of angiotensin-converting enzyme/DD genotype with sarcoidosis susceptibility in Slovenian patients
Barbara Salobir, Igor Medica, Marjeta Tercelj, Andrej Kastrin, Miso Sabovic, Borut PeterlinMed Sci Monit 2007; 13(12): CR538-542 :: ID: 561491
Abstract
Background: Sarcoidosis is a multisystemic chronic inflammatory disorder of unknown etiology with multifactorial genetic predisposition. An elevated ACE serum level is considered to be the activity marker of the disease. The involvement of the ACE I/D polymorphism in sarcoidosis susceptibility has been investigated in different populations, but results have been inconclusive. The purpose of this study was to evaluate the possible association of angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism with sarcoidosis in the Slovene population.
Material/Methods: In 105 sarcoidosis patients (69 female, 36 male, mean age: 41±1 years) and in 80 sex- and age-matched control subjects, genotyping for the ACE gene I/D polymorphism was performed by PCR and restriction enzyme digestion.
Results: An increased frequency of DD homozygotes vs. II homozygotes + ID heterozygotes was found in the group of sarcoidosis patients compared with the control group (OR: 2.19, 95%CI: 1.12–4.26, p=0.02). No differences in genotype frequencies were found in the group of sarcoidosis patients when considering the clinical course or presentation of the disease.
Conclusions: These results indicate that the ACE gene I/D polymorphism might be a risk factor for sarcoidosis susceptibility in the Slovene population and imply the possible role of population origin in the modulation of the influence of ACE gene variability in the pathophysiology of sarcoidosis.
Keywords: Genetic Predisposition to Disease, Peptidyl-Dipeptidase A - genetics, Polymorphism, Genetic, Sarcoidosis - genetics, Slovenia
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Comparing Neuromuscular Blockade Measurement Between Upper Arm (TOF Cuff®) and Eyelid (TOF Scan®) Using Miv...Med Sci Monit In Press; DOI: 10.12659/MSM.943630
11 Mar 2024 : Clinical Research
Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective AdditiveMed Sci Monit In Press; DOI: 10.12659/MSM.942946
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952