29 August 2008
Homeopathic ethanol
Richard M. Kream, George B. StefanoMed Sci Monit 2008; 14(9): SC11-13 :: ID: 867944
Abstract
Ethanol has had a long and deep association with the historical development of world culture. Ostensibly, its consumption has both short and long term positive and negative effects, based on moderate or excessive intake, respectively. The predominant thrust of empirical research, however, into the multiple biological effects of ethanol has led to its negative designation as a major addictive substance. Multiple lines of research have elucidated functional interactions of ethanol in opioid modulation of dopaminergic transmission in CNS reward systems. In parallel, recent work has demonstrated that animal cells have the ability to effect de novo synthesis of chemically authentic morphine from dopamine (DA) and DA-related aromatic precursor molecules. Interestingly, we have observed that sub-threshold concentrations of ethanol alter cellular distributions of endogenously expressed morphine. Reciprocal autocrine/paracrine modulatory effects of very low concentrations of morphine in concert with ethanol also suggest the potential for endogenous expression and action of homeopathic concentrations of ethanol within discrete cellular microdomains. Perturbation of this subtle regulatory relationship by exogenous intake of ethanol may shed light on the biochemical and molecular bases of reward and addictive states.
Keywords: Narcotics - metabolism, Reward, Homeopathy, Morphine - metabolism, Ethanol - therapeutic use, Dopamine - metabolism, Central Nervous System Depressants - therapeutic use, Analgesics, Opioid - metabolism, Alcohol Drinking
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952