Logo Medical Science Monitor Basic Research

Call: 1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research

01 December 2007

Association of angiotensin-converting enzyme/DD genotype with sarcoidosis susceptibility in Slovenian patients

Barbara Salobir, Igor Medica, Marjeta Tercelj, Andrej Kastrin, Miso Sabovic, Borut Peterlin

Med Sci Monit 2007; 13(12): CR538-542 :: ID: 561491

Abstract

Background: Sarcoidosis is a multisystemic chronic inflammatory disorder of unknown etiology with multifactorial genetic predisposition. An elevated ACE serum level is considered to be the activity marker of the disease. The involvement of the ACE I/D polymorphism in sarcoidosis susceptibility has been investigated in different populations, but results have been inconclusive. The purpose of this study was to evaluate the possible association of angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism with sarcoidosis in the Slovene population.
Material/Methods: In 105 sarcoidosis patients (69 female, 36 male, mean age: 41±1 years) and in 80 sex- and age-matched control subjects, genotyping for the ACE gene I/D polymorphism was performed by PCR and restriction enzyme digestion.
Results: An increased frequency of DD homozygotes vs. II homozygotes + ID heterozygotes was found in the group of sarcoidosis patients compared with the control group (OR: 2.19, 95%CI: 1.12–4.26, p=0.02). No differences in genotype frequencies were found in the group of sarcoidosis patients when considering the clinical course or presentation of the disease.
Conclusions: These results indicate that the ACE gene I/D polymorphism might be a risk factor for sarcoidosis susceptibility in the Slovene population and imply the possible role of population origin in the modulation of the influence of ACE gene variability in the pathophysiology of sarcoidosis.

Keywords: Genetic Predisposition to Disease, Peptidyl-Dipeptidase A - genetics, Polymorphism, Genetic, Sarcoidosis - genetics, Slovenia

Comments

Most Viewed Current Articles

13 Apr 2020 : Original article  

Outcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...

DOI :10.12659/MSMBR.920449

Med Sci Monit Basic Res 2020; 26:e920449

11 May 2020 : Original article  

Analysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...

DOI :10.12659/MSMBR.924085

Med Sci Monit Basic Res 2020; 26:e924085

05 Jan 2021 : Review article  

A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...

DOI :10.12659/MSMBR.929207

Med Sci Monit Basic Res 2021; 27:e929207

10 Aug 2020 : Clinical Research  

Effects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...

DOI :10.12659/MSMBR.925264

Med Sci Monit Basic Res 2020; 26:e925264

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416