11 March 2002
Circulating oxidized LDL is associated with increased levels of cell-adhesionmolecules in clinically healthy 58-year old men (AIR study).
Johannes Hulthe, Björn FagerbergMed Sci Monit 2002; 8(3): CR148-152 :: ID: 420912
Abstract
BACKGROUND: Inflammation has been postulated to play an important rolein atherosclerosis development. Recently, research in this field has been focused on the role of modifiedlipoproteins, primarily oxidized low density lipoprotein. Adhesion and transendothelial migration ofcirculating leukocytes, by the action of cell-adhesion molecules, seem to be critical steps in earlyatherogenesis. Previous in vitro studies on the relationship between ox-LDL and the expression of cell-adhesionmolecules on endothelial cells have shown diverging results. Furthermore, there are as yet no reportson the relationship between circulating ox-LDL and cell-adhesion molecules in vivo. MATERIAL/METHODS:The relationship between circulating ox-LDL and adhesion molecules was measured by ELISA in clinicallyhealthy, 58-year-old men recruited from the general population (n=391). RESULTS: The results of the presentstudy showed that circulating ox-LDL was associated with sICAM-1 and sE-selectin, but not with sVCAM-1.After adjustment for other risk factors, i.e. systolic blood pressure, LDL cholesterol, apoB, apoA1 andsmoking, the observed relationships between ox-LDL and sICAM-1 and sE-selectin, respectively, remainedstatistically significant. CONCLUSIONS: The observed results fit into the concept that oxidatively modifiedLDL may regulate the increased expression of cell-adhesion molecules on endothelial cells in vivo. Theseobservations were made in a population-based sample of clinically healthy, middle-aged Caucasian men.Since this was a cross-sectional study no conclusions can be drawn on causality.
Keywords: Cell Adhesion, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Lipoproteins, LDL, Regression Analysis, Research Support, Non-U.S. Gov
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
11 Mar 2024 : Clinical Research
Comparison of Effects of Sugammadex and Neostigmine on Postoperative Neuromuscular Blockade Recovery in Pat...Med Sci Monit In Press; DOI: 10.12659/MSM.942773
12 Mar 2024 : Clinical Research
Comparing Neuromuscular Blockade Measurement Between Upper Arm (TOF Cuff®) and Eyelid (TOF Scan®) Using Miv...Med Sci Monit In Press; DOI: 10.12659/MSM.943630
11 Mar 2024 : Clinical Research
Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective AdditiveMed Sci Monit In Press; DOI: 10.12659/MSM.942946
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952