29 July 2014 : Original article
Brain, Liver, and Serum Salusin-alpha and -beta Alterations in Sprague-Dawley Rats with or Without Metabolic Syndrome
Cihan CitilABCFG, Vahit KonarAG, Suleyman AydinADEFG, Musa YilmazCG, Serdal AlbayrakDG, Ibrahim Hanifi OzercanG, Yusuf OzkanGDOI: 10.12659/MSM.890708
Med Sci Monit 2014; 20:1326-1333
Abstract
BACKGROUND: This metabolic syndrome (MetS) study was designed to investigate changes in expression of the neuropeptides salusin-α (Sal-α) and salusin-β (Sal-β) in brain and liver tissue in response to obesity and related changes induced by high-fructose diet and explored how these changes were reflected in the circulating levels of Sal-α and Sal-b, as well as revealing how the lipid profile and concentrations of glucose and uric acid were altered.
MATERIAL AND METHODS: The study included 14 Sprague-Dawley rats. The control group was fed ad libitum on standard rat pellets, while the intervention group was given water with 10% fructose in addition to the standard rat pellet for 3 months. Sal-α and Sal-β concentrations in the serum and tissue supernatants were measured by ELISA, and immunohistochemical staining was used to demonstrate expression of the hormones in brain and liver.
RESULTS: Sal-α and Sal-β levels in both the serum and the brain and liver tissue supernatants were lower in the MetS group than the control group. Sal-α and Sal-β were shown by immunohistochemistry to be produced in the brain epithelium, the supraoptic nucleus of the hypothalamus, and the liver hepatocytes.
CONCLUSIONS: The decrease in Sal-α and Sal-β might be involved in the etiopathology of the metabolic syndrome induced by fructose.
Keywords: Brain - metabolism, Enzyme-Linked Immunosorbent Assay, Fructose, Intercellular Signaling Peptides and Proteins - metabolism, Liver - metabolism, Metabolic Syndrome X - metabolism, Obesity - metabolism
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