01 September 1997
Bowel ischaemia-reperfusion-induced liver and lung injury: the fundamental role of Eicosanoids and Xanthine oxidase-generated oxygen free radicals
Avi A. Weinbroum, Gideon Goldman, Yoram Kluger, Masoud Hag, Sylvia Marmour, Patrick Sorkine, Joseph M. Klausner, David Niv, Valery RudickMed Sci Monit 1997; 3(5): BR624-630 :: ID: 501505
Abstract
Background: The aim of the study was to assess complementary induction of remote organ injury following bowel ischaemia- reperfusion by eicosanoids and xanthine oxidase.
Material/Methods: Randomized, controlled, animal study. Hospital-based animal research facility. Materials: 40 rats in 5 groups. Sham laparotomy, laparotomy and superior mesenteric artery occlusion (ischaemia 1h) and reperfusion (3h), or laparotomy and arterial occlusion and reperfusion in rats treated with thromboxane synthase inhibitor OKY-046, leukotrienes synthase inhibitor diethylcarbamazine or xanthine oxidase inhibitor allopurinol. Bowel, liver and lung wet: dry weight ratio, tissue: circulation albumin I125, permeability index, polymorphonuclear neutrophils tissue counts.
Results: Ischaemia intestinal and lungs wet: dry ratios increased by 50%; over sham or treatment groups; liver ratios were similar. Albumin indexes in ischaemia organs were 1.5-3 times more than shams and treatment values, and allopurinol normalized it best. Neutrophils counts in all ischaemia organs were double that of shams; allopurinol prevented sequestration completely, eicosanoids inhibitors did so partially.
Conclusions: Xanthine oxidase initiated remote organ injury following bowel ischaemia-reperfusion. Allopurinol prevented it entirely while eicosanoids inhibitors only partially.
Keywords: ischaemia-reperfusion, bowel, remote organ injury, thromboxane, leukotriene, Xanthine Oxidase, oxygen free radicals
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
11 Mar 2024 : Clinical Research
Comparison of Effects of Sugammadex and Neostigmine on Postoperative Neuromuscular Blockade Recovery in Pat...Med Sci Monit In Press; DOI: 10.12659/MSM.942773
12 Mar 2024 : Clinical Research
Comparing Neuromuscular Blockade Measurement Between Upper Arm (TOF Cuff®) and Eyelid (TOF Scan®) Using Miv...Med Sci Monit In Press; DOI: 10.12659/MSM.943630
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952