Relationship Between Composition of Fatty Acid in Platelet Phospholipid Membrane and Markers of Oxidative Stress in Healthy Men and Men After a Myocardial Infarction

Inga Bikulčienė; Neda Garjonytė; Vytautas Žėkas; Rėda Matuzevičienė; Živilė Žymantienė; Aldona Baublytė; Vaiva Hendrixson; Dovilė Karčiauskaitė; Algirdas Utkus; Arvydas Kaminskas

doi:10.12659/MSMBR.929634

15 February 2021: Human Study

Relationship Between Composition of Fatty Acid in Platelet Phospholipid Membrane and Markers of Oxidative Stress in Healthy Men and Men After a Myocardial Infarction

Inga Bikulčienė ^1ABCDEF* , Neda Garjonytė ^1CDF , Vytautas Žėkas ^1B , Rėda Matuzevičienė ^1CD , Živilė Žymantienė ^2B , Aldona Baublytė ^3CG , Vaiva Hendrixson ^1E , Dovilė Karčiauskaitė ^1ADG , Algirdas Utkus ^4DG , Arvydas Kaminskas ^1ADG

DOI: 10.12659/MSMBR.929634

Med Sci Monit Basic Res 2021; 27:e929634

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Table 2 A comparison of the composition of fatty acids in the phospholipid membrane of platelets between post-myocardial infarction patients and the control group of healthy individuals.

FAs (provided by percentage of total amount)	Median, minimum, maximum	Control group of healthy individuals (N=79)	Post-myocardial infarction patients (N=20)	P value
C 14: 0^*	Median	3.08	3.02	0.499
	Minimum	0.81	2.29
	Maximum	8.75	7.35
	IQR	1.99	2.08
C 16: 0	Median	47.00	46.17	0.713
	Minimum	20.53	23.76
	Maximum	65.11	58.96
	IQR	13.71	14.55
C 18: 0	Median	20.47	18.47	0.217
	Minimum	8.76	6.92
	Maximum	43.87	26.56
	IQR	6.11	6.57
C 16: 1ω7^**	Median	1.46	2.22	0.117
	Minimum	0.18	0.52
	Maximum	15.7	26.03
	IQR	1.46	2.00
C 18: 1ω7	Median	1.24	1.55	0.057
	Minimum	0.13	0.54
	Maximum	6.90	3.00
	IQR	0.94	1.35
C 18: 1ω9	Median	7.11	6.21	0.971
	Minimum	0.46	1.91
	Maximum	22.05	16.91
	IQR	7.45	7.51
C 20: 1ω9	Median	3.09	1.38
	Minimum	0.36	0.69
	Maximum	56.77	8.14
	IQR	3.46	0.91
C 18: 2ω6	Median	6.25	8.45
	Minimum	0.40	2.29
	Maximum	21.46	15.27
	IQR	7.87	6.05
C 18: 3ω3	Median	1.55	1.29	0.917
	Minimum	0.03	0.30
	Maximum	21.66	5.55
	IQR	2.00	1.61
C 20: 4ω6	Median	0.90	2.02
	Minimum	0.02	0.67
	Maximum	9.10	6.65
	IQR	1.46	2.31
C 20: 5ω3	Median	0.38	0.88
	Minimum	0.05	0.46
	Maximum	3.75	1.84
	IQR	0.68	0.48
C 22: 5ω3	Median	0.51	0.86	0.084
	Minimum	0.02	0.19
	Maximum	2.76	2.54
	IQR	0.66	0.55
C 22: 6ω3	Median	0.62	1.12
	Minimum	0.02	0.18
	Maximum	3.95	2.51
	IQR	1.02	0.88
∑ SFA (C 14: 0 + C 16: 0 + C 18: 0)	Median	70.86	69.34	0.547
	Minimum	31.17	35.25
	Maximum	93.0	85.68
	IQR	21.49	21.40
∑ MUFA	Median	15.8	13.91	0.469
	Minimum	3.69	5.04
	Maximum	62.8	43.88
	IQR	9.84	7.99
∑ PUFA	Median	10.99	16.78
	Minimum	1.33	6.28
	Maximum	34.97	25.64
	IQR	10.27	10.37
∑ ω3	Median	3.85	4.36	0.144
	Minimum	0.59	1.88
	Maximum	25.46	10.38
	IQR	3.41	3.16
∑ ω6	Median	7.44	10.81
	Minimum	0.49	3.29
	Maximum	28.28	18.90
	IQR	9.02	8.01
Ratio of ω3/ω6	Median	0.47	0.48	0.749
	Minimum	0.08	0.23
	Maximum	8.21	1.033
	IQR	0.84	0.37
Ratio of PUFA/SFA	Median	0.15	0.25
	Minimum	0.01	0.07
	Maximum	0.7	0.59
	IQR	0.18	0.21
Ratio of C 18: 2ω6/ C 20: 4ω6	Median	6.12	3.20
	Minimum	0.54	1.19
	Maximum	118.0	21.61
	IQR	7.61	4.43
Ratio of C 18: 3ω3/ C 20: 5ω3	Median	3.65	1.76
	Minimum	0.04	0.38
	Maximum	83.31	9.10
	IQR	6.22	1.47
Ratio of C 20: 4ω6/ C 20: 5ω3	Median	1.98	1.49	0.861
	Minimum	0.09	0.72
	Maximum	17.70	14.46
	IQR	2.94	2.38
SFAs – saturated fatty acids; MUFAs – monounsaturated fatty acids; PUFAs – polyunsaturated fatty acids; FAa – fatty acids; ^* number of carbon atoms and double bonds; ^** position of double bond between carbon atoms in the molecule; ∑ – total sum in percentages.

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Relationship Between Composition of Fatty Acid in Platelet Phospholipid Membrane and Markers of Oxidative Stress in Healthy Men and Men After a Myocardial Infarction

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