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03 May 2021: Meta-Analysis

The Roles of Reduced Folate Carrier-1 (RFC1) A80G (rs1051266) Polymorphism in Congenital Heart Disease: A Meta-Analysis

Kang Yi 12ABCDEF* , Yu-Hu Ma 23ABCDEF* , Wei Wang 23BCF , Xin Zhang 24BCF , Jie Gao 23BCD , Shao-E He 25BCD , Xiao-Min Xu 23CDF , Meng Ji 23CDF , Wen-Fen Guo 6ADEG* , Tao You 12ABCDEFG*

DOI: 10.12659/MSM.929911

Med Sci Monit 2021; 27:e929911

Table 4 Meta-analysis of reduced folate carrier-1 (RFC1) A80G polymorphism and fetal congenital heart disease risk.

TypeOR (95%CI)zPTest of heterogeneityAnalysis model
I2p*
GA VS GG1.36 [1.06, 1.75]2.40.0200.51Fixed-effects model
AA VS GG0.99 [0.74, 1.34]0.040.97110.34Fixed-effects model
GA+AA VS GG1.24 [0.98, 1.57]1.790.0700.58Fixed-effects model
AA VS GG+GA0.83 [0.65, 1.06]1.520.13380.17Fixed-effects model
A VS G1.02 [0.88, 1.18]0.210.8490.36Fixed-effects model
GA VS GG1.33 [0.98, 1.79]1.840.0750.37Fixed-effects model
AA VS GG1.16 [0.83, 1.64]0.870.3900.69Fixed-effects model
GA+AA VS GG1.29 [0.97, 1.70]1.780.0800.45Fixed-effects model
AA VS GG+GA0.97 [0.73, 1.29]0.190.8500.66Fixed-effects model
A VS G1.09 [0.92, 1.30]0.980.3200.57Fixed-effects model

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416