26 May 2021 : Laboratory Research
Cytotoxicity and Antiplasmodial Properties of Different Hylocereus polyrhizus Peel Extracts
Rudi Hendra12ABCDEFG*, Rohimatul Khodijah1B, Rianti Putri3BC, Riezki Amalia24BC, Yuli Haryani1DF, Hilwan Yuda Teruna1DEF, Rizky Abdulah24DEFDOI: 10.12659/MSMBR.931118
Med Sci Monit Basic Res 2021; 27:e931118
Table 1 Toxicity, cytotoxicity, and antiplasmdodial activity of peels of H. polyrhizus extracts.
| Extract | Yield (% g/g fresh sample) | Toxicity (LC50; μg/mL) | Cytotoxicity (IC50; μg/mL) | Antiplasmodial (IC50; μg/mL) | |
|---|---|---|---|---|---|
| SK-OV-3 | HeLa | ||||
| Pigment | 0.82 | >1000 | >1000 | >1000 | >100 |
| -Hexane | 1.04 | 23.6±0.40 | >1000 | >1000 | 6.51±0.49 |
| Dichloromethane | 1.02 | 10.32±0.13 | 560.86±0.63 | >1000 | 2.13±0.42 |
| Ethyl acetate | 2.26 | 148.93±0.57 | >1000 | >1000 | >100 |
| SK-OV-3 – ovarian cancer cell line; HeLa – cervical cancer cell line. The biological activities were tested in triplicate and reported as mean±standard deviation. | |||||