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07 January 2022: Meta-Analysis

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Disease: A Meta-Analysis

Wenjie Sun AE , Junqiang Yan AFG* , Jiannan Wu BC , Hongxia Ma BD

DOI: 10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Table 3 Methods of measuring primary outcomes and summary of finding (SoF). GRADEprofiler was used to create the table.

OutcomesStudy ID/number of participants (PD/control)Summary of findings
Videnovic 2017Rutten 2016–2019Rutten 2019Raymackers 2019Willis 2018
16/1535/3745/478/810/10Difference from pre to post (95% CI)No of participants (studies)Quality of the evidence (GRADE)
Motor functionUPDRS IIIUPDRS IIIUPDRS IIIUPDRS III4.68 lower (8.25 to 1.12 lower)209 (4 studies)⊕⊕⊕⊕ high
DepressionBDIHDRSBDIHADS (depression)BDI0.27 standard deviations lower (0.52 to 0.01 lower)234 (5 studies)⊕⊕⊕⊕ high
Daytime sleepinessESSSCOPA (daytime sleepiness)ESSESSESS0.14 standard deviations lower (0.39 lower to 0.11 higher)241 (5 studies)⊕⊕⊕⊕ high
SleepPDSSPDSS3.45 standard deviations higher (0.12 to 6.78 higher)122 (2 studies)⊕⊕⊕⊕ high
Adverse eventsRR 1.73 (1.19 to 2.52)231 (5 studies)⊕⊕⊕⊕ high
SCOPA (daytime sleepiness) – Scales for Outcomes in Parkinson’s Disease (daytime sleepiness); PDSS – Parkinson’s Disease Sleep Scale; FSS – Fatigue Severity Scale; FIS – Fatigue Impact Scale; BBS – Brief Bronowski Scale; BAI – Beck Anxiety Inventory; PDQ-39; WHO-QOL – World Health Organization-Quality of Life assessment.
* The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI – confidence interval; RR – risk ratio;
GRADE Working Group grades of evidence. Further research is very unlikely to change our confidence in the estimate of effect. Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. We are very uncertain about the estimate.

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416