07 July 2022>: Laboratory Research
Cytotoxicity, Apoptosis, Migration Inhibition, and Autophagy-Induced by Crude Ricin from Seeds in A549 Lung Cancer Cell Lines
Irma Erika Herawati 12ABCDEF , Ronny Lesmana 345ABDEF , Jutti Levita ABD1EF , Anas Subarnas 1ABCDEFG*DOI: 10.12659/MSMBR.936683
Med Sci Monit Basic Res 2022; 28:e936683
Table 1 Percentage of viable, early apoptotic, late apoptotic, and necrotic A549 cancer cells in the cisplatin and crude ricin (CR) treatment with significant effect between control and CR in stage of apoptosis (a,b,c).
Treatment (ppm) | Viable cells (Q4) | Early apoptosis (Q3) | Late apoptosis (Q2) | Necrosis (Q1) |
---|---|---|---|---|
Control | 96.85±0.42 | 1.49±0.085 | 1.56±0.12 | 0.32±0.54 |
Cisplatin 0.5 | 82.65±0.14 | 7.94±1.67 | 6.16±0.47 | 4.37±1.29 |
Cisplatin 1 | 86.40±5.80 | 5.70±1.24 | 5.01±2.02 | 1.74±5.02 |
Cisplatin 2 | 77.20±0.28 | 15.40±0.05 | 6.41±0.21 | 1.29±0.57 |
CR 0.5 | 66.85±0.79 | 25.80±0.09 | 6.82±0.18 | 0.54±0.71 |
CR 1 | 53.65±0.78 | 35.90±1.68 | 7.99±5.04 | 2.45±0.71 |
CR 2 | 49.30±15.70 | 38.35±1.37 | 8.83±1.99 | 3.58±15.06 |