24 November 2022>: Human Study
FLT3 Gene Mutations in Acute Myeloid Leukemia Patients in Northeast Thailand
Nang Ei Ei Aung 1BCD , Supawadee Yamsri 2ACDE* , Nattiya Teawtrakul 3B , Piyawan Kamsaen 4B , Supan Fucharoen 2DGDOI: 10.12659/MSMBR.937446
Med Sci Monit Basic Res 2022; 28:e937446
Table 1 Characteristics and laboratory data of 65 newly diagnosed acute myeloid leukemia (AML) patients according to type of FLt3 mutation.
Characteristics | Mutations in patients with AML | ||||
---|---|---|---|---|---|
Wild type (n=48) | All mutations (n=17) | FLT3-ITD (n=10) | FLT3-TKD (n=6) | Dual ITD & TKD* (n=1) | |
Sex | |||||
Male; n (%) | 13 (27.1) | 4 (23.5) | 2 (20) | 1 (16.7) | 1 (100) |
Female; n (%) | 35 (72.9) | 13 (76.5) | 8 (80) | 5 (83.3) | – |
Age | |||||
Median | 43 | 49 | 57.5 | 44 | 59 |
IQRs | 18.3–61.5 | 18.3–63.2 | 24.5–66.5 | 14.5–52.6 | – |
Number of adult (>18 y) | 36 | 13 | 8 | 4 | 1 |
Number of children (≤18 y) | 12 | 4 | 2 | 2 | – |
WBC (×10/μL) | |||||
Median | 14.7 | 34.0** | 90.3** | 17.3 | 89.4 |
IQR | 4.9–24.3 | 13.3–193.3 | 26.6–535.0 | 8.3–75.4 | – |
Hemoglobin (g/dL) | |||||
Median | 8.2 | 7.0 | 6.4 | 8.4 | 7.8 |
IQR | 7.0–9.2 | 5.7–8.4 | 5.4–8.5 | 6.2–8.4 | – |
Platelets count (×10/μL) | |||||
Median | 69 | 36 | 36 | 47 | 38 |
IQRs | 41.3–145.0 | 19.0–47.0 | 21.0–40.5 | 19.0–120.0 | – |
Peripheral blood blast (%) | |||||
Median | 43 | 40.5 | 80** | 13** | 93 |
IQRs | 21.0–69.0 | 10.8–91.8 | 49.8–97.3 | 3.8–17.7 | – |
Bone marrow blast (%) | |||||
Median | 51a | 82.4b | 82.8,c | 82.4d | 82 |
IQRs | 33.9–77.8 | 56.7–82.8 | 69.0–90.6 | 33.9–59.5 | – |
Overall survival (days) | |||||
Median | 36 | 18 | 21.5 | 11 | 11 |
IQRs | 23.0–135.5 | 7.0–180.0 | 9.8–141.3 | 5.0–183.0 | – |
FAB subtype | |||||
AML-M3; N (%) | 7 (14.6) | 5 (29.4) | 3 (30) | 2 (33.3) | – |
AML-non-M3; N (%) | 41 (85.4) | 12 (70.6) | 7 (70) | 4 (66.7) | 1 (100) |
* Presented as raw data; ** statistically significant from wild type ( a,b,c,d Data from 39, 13, 7, and 5 patients, respectively. FLT3 – FMS-like tyrosine kinase 3; IQR – interquartile range; ITD – internal tandem duplication; TKD – tyrosine kinase domain. |