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24 November 2022: Human Study

FLT3 Gene Mutations in Acute Myeloid Leukemia Patients in Northeast Thailand

Nang Ei Ei Aung 1BCD , Supawadee Yamsri 2ACDE* , Nattiya Teawtrakul 3B , Piyawan Kamsaen 4B , Supan Fucharoen 2DG

DOI: 10.12659/MSMBR.937446

Med Sci Monit Basic Res 2022; 28:e937446

Table 2 Characteristics of patients with FMS-like tyrosine kinase 3 (FLT3)-tyrosine kinase domain (TKD) mutations.

MutationsCharacteristics of mutations*Characteristics of patients
Amino acid changeFATHMM predictionType of mutationDrug resistanceAge/sexFAB subtypeWBC count (μL)PB blast%
835GT – GT (c.2504A>T)p.Asp835ValPathogenic (score 0.99)Substitution – missenseQuizartinib39/FAML-M370 6605
49/FAML-nonM312 1409
49/FAML-nonM322 50017
15/FAML-nonM310 5800
835AT – AT (c.2503G>C)p.Asp835HisPathogenic (score 0.99)Substitution – missenseSorafenib13/FAML-M3137017
836AT – AT (c.2508C>A)p.Ile836=Neutral (score 0.11)Substitution – coding silentn/a64/MAML-nonM389 59020
836AT – AT (c.2508C>G)p.Ile836MetNeutral (score 0.20)Substitution – missensen/a59/MAML-nonM389 40093
* From COSMIC database () []. n/a – not available.

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416