24 November 2022 : Clinical Research
FLT3 Gene Mutations in Acute Myeloid Leukemia Patients in Northeast Thailand
Nang Ei Ei Aung1BCD, Supawadee Yamsri2ACDE*, Nattiya Teawtrakul3B, Piyawan Kamsaen4B, Supan Fucharoen
2DG
DOI: 10.12659/MSMBR.937446
Med Sci Monit Basic Res 2022; 28:e937446
Table 3 Frequency of FMS-like tyrosine kinase 3 (FLT3)-ITD and tyrosine kinase domain (TKD) mutations in patients with acute myeloid leukemia (AML) from various studies in Asia.
| Country | Study design | Age | N | FLT3-ITD (%) | FLT3-TKD | |
|---|---|---|---|---|---|---|
| (%) | Type of mutations | |||||
| This study (Northeast) | Prospective | ≥18 y | 36 | 18.4 | 510.2 | Asp835ValAsp835HisIle836=Ile836Met |
| <18 y | 12 | 12.5 | 12.5 | |||
| Kumsaen et al (2016) [] (Northeast)19 | Prospective | ≥18 y | 38 | 21.1 | n/a | n/a |
| <18 y | 14 | 14.3 | ||||
| Mukda et al (2011) [] (Northeast)19 | Prospective | <18 y | 64 | 6.3 | 4.8 | n/a |
| Auewarakul et al (2015) [] (Central)17 | Prospective | ≥18 y | 256 | 24.6 | 3.1 | Asp835TyrAsp835HisAsp835GluAsp835AlaI836 deletionAsp835Del +Ile836Val |
| Mevatee et al (2015) [] (North)18 | Prospective | ≥18 y | 40 | 25 | n/a | n/a |
| Yusoff et al (2019) []20 | Prospective | ≥16 y | 102 | 19 | 3 | n/a |
| Mehta et al (2012) []21 | Prospective | ≥15 y | 116 | 19 | 6.9 | n/a |
| <15 y | 28 | 17.9 | 3.6 | |||
| Wang et al (2005) []23 | Prospective | ≥15 y | 143 | 25.9 | 6.3 | Asp835Tyr (data from 1 sample) |
| Liang et al (2003) []22 | Prospective | <18 y | 91 | n/a | 3.3 | Asp835TyrAsp835HisAsp835Val |
| Shih et al (2003) []24 | Retrospective (APL only) | >15 y | 94 | 20.2 | 19.1 | Asp835TyrAsp835HisAsp835Val |
| ≤15 y | 13 | 20 | 15.3 | |||
| Yamamoto et al (2001) []25 | Prospective | >15 y | 429 | 20 | 7 | Asp835TyrAsp835HisAsp835ValAsp835Glu |
| n/a – not available. | ||||||