Urinary Klotho Excretion: A Key Regulator of Sodium Homeostasis in Chronic Kidney Disease Stage 2-4

06 November 2023: Human Study

Urinary Klotho Excretion: A Key Regulator of Sodium Homeostasis in Chronic Kidney Disease Stage 2–4

Po-Jui Chi ^12ABCDEF , Chung-Jen Lee ^3BCD , Shih-Yuan Hung ^12CD , Jen-Pi Tsai ^45ABC , Hung-Hsiang Liou ^16ACDE*

DOI: 10.12659/MSMBR.942097

Med Sci Monit Basic Res 2023; 29:e942097

Table 3 Univariate and multivariate stepwise linear regression of log-FENa in patients with chronic kidney disease.

Variables	log-FENa
	Univariate		Multivariate
	β	P	β	Adjusted R2 change	P
eGFR	−0.032	^*
Hemoglobin	−0.202	0.001^*
log-FEK	0.496	0.0001^*
log-FECa	0.472	0.005^*
FEPi	0.05	^*	0.027	0.1	0.002^*
FEMg	0.199	^*	0.133	0.471	^*
log-UPCR	0.223	0.024^*
log-C-terminal FGF23	0.538	0.014^*
log-FEKlotho	0.289	0.001^*	0.138	0.039	0.032^*
eGFR – estimated glomerular filtration rate; FENa – fractional excretion of sodium; FEK – fractional excretion of potassium; FECa – fractional excretion of calcium; FEPi – fractional excretion of phosphate; FEMg – fractional excretion of magnesium. Multivariate stepwise regression included adjusted eGFR, hemoglobin, log-FEK, log-FECa, FEPi, FEMg, log-UPCR, log-C-terminal FGF23, log-FEKlotho. ^* Values of