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02 January 2022: Clinical Research

Retrospective Study of 573 Patients with Heart Failure Evaluated for Coronary Artery Disease at Toulouse University Center, France

Antoine Deney 1ABCDEF* , Vanessa Nader 12ABCDEF* , Anthony Matta 13ABCDE , Romain Itier 1CDE , Pauline Fournier 1ABCD , Olivier Lairez 1ADF , Nathalie Pizzinat 4ACD , Didier Carrié 1ACD , Frédéric Boal 4ACD , Michel Galinier 1ACD , Oksana Kunduzova 4ACD , Rania Azar 2ACD , Jerome Roncalli 14ABCDEFG*

DOI: 10.12659/MSM.934804

Med Sci Monit 2022; 28:e934804

Table 1 Characteristics of the studied population stratified by type of heart failure.

Studied populationN=573HFpEFN=89HFrEFN=484P-value
Age68.28±12.2572.53±9.7267.50±12.51
Male sex438 (76.44%)63 (70.78%)375 (77.48%)0.171
BMI27.89±18.10427.65±6.56527.93±19.5010.893
Coronary artery disease320 (55.84%)50 (56.18%)270 (55.78%)0.945
Atrial fibrillation174 (30.37%)25 (28.09%)149 (30.78%)0.611
Chronic kidney disease266 (46.42%)45 (50.56%)221 (45.66%)0.500
Dyslipidemia164 (28.62%)39 (43.82%)125 (25.83%)0.001
Diabetes mellitus171 (29.84%)29 (32.58%)142 (29.34%)0.711
Hypertension309 (53.93%)61 (68.54%)248 (51.24%)0.006
Smoking144 (25.13%)11 (12.36%)133 (27.48%)0.001
Family history89 (15.53%)11 (12.36%)78 (16.12%)0.289
Valvulopathy224 (39.09%)29 (32.58%)195 (40.29%)0.181
Right ventricular dysfunction110 (19.20%)6 (6.74%)104 (21.49%)0.535
TAPSE16.77±4.4516.45±3.48816.78±4.500.811
PAPSE41.38±13.3040.62±10.2641.46±3.630.829
Pacemaker41 (7.16%)6 (6.74%)35 (7.23%)0.858
Defibrillator38 (6.63%)1 (1.12%)37 (7.64%)0.023
NYHA class
 123 (4.01%)04 (0.82%)0.433
 2143 (24.96%)17 (19.10%)126 (26.03%)
 3149 (26.00%)20 (22.47%)129 (26.65%)
 447 (8.20%)4 (4.49%)43 (8.88%)
Systolic blood pressure128.86±22.80137.72±22.43127.37±22.550.001
Diastolic blood pressure75.27±15.8472.92±20.5675.67±14.900.197
Heart rate82.07±20.7977.91±17.9582.76±21.160.081
Troponin143.87±543.08112.13±212.21149.21±580.790.726
NT-ProBNP5535.15±8523.844073.81±7245.545770.14±8697.020.140
β-blockers324 (56.54%)41 (46.06%)283 (58.47%)0.030
Diuretics328 (57.24%)50 (56.18%)278 (57.44%)0.809
Mineralocorticoids95 (16.58%)11 (12.36%)84 (17.35%)0.277
ACE/ARA289 (50.44%)51 (57.30%)238 (49.17%)0.164
ARNI45 (7.85%)3 (3.37%)42 (8.68%)0.087
Ivabradine7 (1.22%)07 (1.45%)0.603
SAPT172 (30.02%)36 (40.45%)136 (28.10%)0.041
DAPT47 (8.20%)8 (9.00%)39 (8.05%)0.893
DOAC+AVK165 (28.79%)27 (30.33%)138 (28.51%)0.799
AAP+OAC35 (6.11%)6 (6.74%)29 (6.00%)0.893
β-blockers480 (83.77%)58 (65.17%)422 (87.19%)
Diuretics439 (76.61%)62 (69.66%)377 (77.89%)0.067
Mineralocorticoids231 (40.31%)19 (21.35%)212 (43.80%)
ACE/ARA332 (57.94%)65 (73.03%)267 (55.16%)0.002
ARNI137 (23.90%)4 (4.49%)133 (27.48%)
Ivabradine19 (3.32%)2 (2.25%)17 (3.51%)0.752
SAPT120 (20.94%)33 (37.08%)87 (17.97%)
DAPT215 (37.52%)29 (32.58%)186 (38.43%)0.256
DOAC+AVK217 (37.87%)31 (34.83%)186 (38.43%)0.480
AP+OAC82 (14.31%)11 (12.36%)71 (14.67%)0.569
BMI – body mass index; APT – single anti-platelet therapy; DAPT – dual anti-platelet therapy; DOAC – direct oral anti-coagulant; AP+OAC – anti-platelet +oral anti-coagulant.

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416