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Moving Back to the Future: Use of Organ Care System Lung for Lobectomy Before Lobar Lung Transplantation

Anton Sabashnikov, Mohamed Zeriouh, Prashant N. Mohite, Nikhil P. Patil, Diana García-Sáez, Bastian Schmack, Simona Soresi, Pascal M. Dohmen, Aron-Frederik Popov, Alexander Weymann, André R. Simon, Fabio De Robertis

(Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Harefield, Middlesex, United Kingdom)

Med Sci Monit Basic Res 2016; 22:70-74

DOI: 10.12659/MSMBR.900200

Published: 2016-07-13


BACKGROUND: Lung transplantation remains the gold standard treatment for patients with end-stage lung disease. Lobar lung transplantation allows for transplantation of size-mismatch donor lungs in small recipients; however, donor lung volume reduction represents a challenging surgical technique. In this paper we present our initial experience with bilateral lobectomy in donor lungs before lobar lung transplantation using normothermic perfusion on the Organ Care System (OCS) Lung.
MATERIAL AND METHODS: Specifics of the surgical technique for donor lung instrumentation on the OCS, lobar dissection on the OCS, and right and left donor lobectomies are presented in detail.
RESULTS: Potential advantages of the use of the OCS for lobectomy for lobar lung transplantation are described in this section. Donor lung volume reduction utilizing OCS appeared to be easier and safer compared to the conventional cold storage technique, due to continuous perfusion of the lungs with blood and well-distended vessels that offer the feel of live lobectomy. Moreover, the OCS represents a platform for donor organ assessment and optimization of its function before transplantation.
CONCLUSIONS: Donor lung volume reduction was safe and feasible utilizing the OCS, which could be a useful tool for volume reduction in cases of size mismatch. Further research is needed to evaluate early and long-term results after lobar lung transplantation using the OCS in clinical studies.

Keywords: acute lung injury, Cardiac Electrophysiology, Heart-Lung Transplantation



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