Scimago Lab
powered by Scopus
eISSN: 2325-4416
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST




Home Page

Medical Science Monitor Basic Research has been selected for the ESCI - Emerging Sources Citation Index (Thomson Reuters, Web of Science, ISI), launching in November 2015 as a new edition of the Web of Science.

read more

Published: 2021-06-09



Vitamin D Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in A549 Cells by Downregulating Inflammatory Cytokines

Vesara A. Gatera, Ronny Lesmana, Ida Musfiroh, Raden Tina D. Judistiani, Budi Setiabudiawan, Rizky Abdulah ORCID logo

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia

Med Sci Monit Basic Res 2021; 27:e931481

ID: 931481

BACKGROUND: Studies have shown that lung inflammation affects lung function, with life-threatening results. Vitamin D may play an important role in inhibiting inflammatory cytokines. Vitamin D deficiency is related to several lung problems, including respiratory distress syndrome, alveolar inflammation, epithelial damage, and hypoxia. Few studies have evaluated the benefits of vitamin D in preventing inflammation in alveolar cells.
MATERIAL AND METHODS: We developed a cell inflammation model induced by lipopolysaccharide (LPS) treatment. The effects of vitamin D on LPS-induced inflammation in A549 cells were examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the anti-inflammatory mechanism of vitamin D was evaluated using western blot analysis.
RESULTS: Our results indicated that vitamin D promoted A549 cell survival following LPS-induced inflammation by downregulating nuclear factor nuclear factor kappa light chain enhancer of activated B cells, tumor necrosis factor-alpha, interleukin (IL)-1ß, IL-6, and IL-12.
CONCLUSIONS: Our results indicated that vitamin D has the potential to manage lung inflammation, although further studies are needed.

Keywords: 1,25-dihydroxyvitamin d, Cytokines, Inflammation, Lipopolysaccharides, Lung

Related articles (0)

Coming soon

Published: 2021-05-26


Cytotoxicity and Antiplasmodial Properties of Different Hylocereus polyrhizus Peel Extracts

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Pekanbaru, Indonesia

Rudi Hendra, Rohimatul Khodijah, Rianti Putri, Riezki Amalia, Yuli Haryani, Hilwan Yuda Teruna, Rizky Abdulah

Med Sci Monit Basic Res 2021; 27:e931118

DOI: 10.12659/MSMBR.931118

Published: 2021-05-11


Kangfuxin Liquid Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Ulcerative Colitis in Mice by Mod...

Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, Yunnan, China (mainland)

Miao Tang, Lian-Li Ni, Jing-Lei Xu, Yu-Jia Wang, Cheng-Gui Zhang, Tahir Ali, Xiu-Mei Wu, Heng Liu, Miao He

Med Sci Monit Basic Res 2021; 27:e930887

DOI: 10.12659/MSMBR.930887