Scimago Lab
powered by Scopus
eISSN: 2325-4416
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST




Home Page

Medical Science Monitor Basic Research has been selected for the ESCI - Emerging Sources Citation Index (Thomson Reuters, Web of Science, ISI), launching in November 2015 as a new edition of the Web of Science.

read more

Published: 2021-10-01



Electroacupuncture Inhibits Myelin Sheath Injury in the Internal Capsule After Focal Cerebral Infarction in Rats Through the Nogo-A/NgR Signaling Pathway

Wenqing Dong, Huachun Miao, Huaibin Li, Feng Wu

Department of Human Anatomy, Wannan Medical College, Wuhu, Anhui, China (mainland)

Med Sci Monit Basic Res 2021; 27:e933253

DOI: 10.12659/MSMBR.933253

BACKGROUND: Ischemic stroke is usually accompanied by white matter damage. The effect of electroacupuncture (EA) on ameliorating white matter damage is still unclear. The purpose of this study was to explore the precise mechanism of EA in treating ischemic white matter.
MATERIAL AND METHODS: In this study, 40 Sprague-Dawley rats were randomly divided into 4 groups: normal group, the sham-operated group, model group, and EA group. The stroke model was established by right middle cerebral artery occlusion, and EA was performed 24 h after the operation for 30 min per day. After 14 days of treatment, brain tissue samples were collected. Hematoxylin and eosin and Luxol fast blue staining were used to observe the changes of white matter damage in the internal capsule (IC). The expression levels of myelin basic protein (MBP), Nogo-A, and Nogo-A receptor (NgR) were detected by immunohistochemistry and western blot.
RESULTS: Compared with the sham-operated group, the model group had decreased expression of MBP and significantly increased expression of Nogo-A and NgR (P<0.05). Compared with the model group, the IC damage was alleviated in the EA group. Immunohistochemistry and western blot analysis showed that EA significantly increased the expression of MBP in white matter (P<0.05) and downregulated the expression levels of Nogo-A and NgR (P<0.05).
CONCLUSIONS: The results of this study indicate that EA can inhibit the expression of Nogo-A/NgR and promote myelin sheath regeneration.

Keywords: cerebral infarction, Electroacupuncture, Internal Capsule, Myelin Sheath, Nogo Proteins

Related articles (0)

Coming soon

Published: 2021-09-13


Size of Acute Myocardial Infarction Correlates with Earlier Time of Initiation of Reperfusion Therapy wit...

Clinic for Cardiology, University Clinical Center of Kosovo, Prishtina, Kosovo

Hajdin Çitaku, Ramë Miftari, David Stubljar, Xhevdet Krasniqi

Med Sci Monit Basic Res 2021; 27:e933214

DOI: 10.12659/MSMBR.933214

Published: 2021-08-23


Influence of Severe Thoracic Trauma on Choosing the Correct Surgical Strategy in Patients with Polytrauma...

University for Business and Technology, Prishtina, Kosovo

Shqiptar Demaçi, Saudin Maliqi, Frederik Çuperjani, Avni Behluli, Fitim Selimi, Fadil Gradica, Burbuqe Bruçi, Tomislav Jukic, David Stubljar, Xhevdet Aliu

Med Sci Monit Basic Res 2021; 27:e932463

DOI: 10.12659/MSMBR.932463