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Medical Science Monitor Basic Research has been selected for the ESCI - Emerging Sources Citation Index (Thomson Reuters, Web of Science, ISI), launching in November 2015 as a new edition of the Web of read more


Published: 2018-10-16

Contribution of Physical and Motor Characteristics to Functional Performance in Children and Adolescents with Down Syndrome: A Preliminary Study

Samire Beqaj, Esmira E.T. Tërshnjaku, Merita Qorolli, Vujica Zivkovic

(Department of Physiotherapy, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo)

Med Sci Monit Basic Res 2018; 24:159-167

DOI: 10.12659/MSMBR.910448


BACKGROUND: Down syndrome (DS) is the most frequent genetic mental disability. Individuals with DS experience a variety of physical, motor, and functional challenges throughout the lifespan. However, the inter-relatedness between these domains is relatively unexplored in children with DS. This study aimed to determine which physical and motor characteristics contribute to functional performance in children and adolescents with DS. It also investigated the relationship between physical, motor, and functional domains.
MATERIAL AND METHODS: We enrolled 44 children and adolescents with DS, ages 3–18 years, in this cross-sectional study. The participants were assessed for functional skills (PEDI-CAT), gross motor skills (GMFM-88), balance (PBS), fine motor skills (Nine-hole peg test), grip strength (hand-held Jamar dynamometer), and body mass index (BMI). Descriptive statistics, Pearson’s correlation, and stepwise linear regression were employed for statistical analysis.
RESULTS: Fine motor skills and grip strength were found to be significant predictors of functional performance. All measures, except BMI, were significantly correlated with each other. The participants scored below standard values in all 4 domains of PEDI-CAT, with the social/cognitive skills being most impaired, while mobility proficiency was found to be participants’ strongest asset.
CONCLUSIONS: This study demonstrated fine motor skills and grip strength to be predictors of functional performance in children and adolescents with DS. It also showed a high level of inter-relatedness between the variables of physical, motor, and functional domains in this population.

Keywords: Activities of Daily Living, Down Syndrome, Hand Strength, Motor Skills




Published: 2018-10-09

Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteol...


Ardeshir Moayeri, Maryam Azimi, Elahe Karimi, Ali Aidy, Naser Abbasi

Med Sci Monit Basic Res 2018; 24:151-158

DOI: 10.12659/MSMBR.909930

Published: 2018-10-02

DNA Repair Gene (XPD, XRCC4, and XRCC1) Polymorphisms in Patients with Endometrial Hyperplasia: A Pilot S...


Ebru Öztürk, Sacide Pehlivan, Ozcan Balat, Mete Gurol Ugur, Huseyin Caglayan Ozcan, Suna Erkılıç

Med Sci Monit Basic Res 2018; 24:146-150

DOI: 10.12659/MSMBR.911041