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17 March 2017 : Meta-Analysis  

Platelets Cellular and Functional Characteristics in Patients with Atrial Fibrillation: A Comprehensive Meta-Analysis and Systematic Review

Alexander Weymann1ABCDEFG*, Sadeq Ali-Hasan-Al-Saegh2ABCDEFG, Anton Sabashnikov34ABCDEFG, Aron-Frederik Popov5ABCDEFG, Seyed Jalil Mirhosseini2ABCDEFG, Luis Nombela-Franco6ABCDEFG, Luca Testa7ABCDEFG, Mohammadreza Lotfaliani2ABCDEFG, Mohamed Zeriouh34ABCDEFG, Tong Liu8ABCDEFG, Hamidreza Dehghan9ABCDEFG, Senol Yavuz10ABCDEFG, Michel Pompeu Barros de Oliveira Sá111213ABCDEFG, William L. Baker14ABCDEFG, Jae-Sik Jang15ABCDEFG, Mengqi Gong8ABCDEFG, Umberto Benedetto16ABCDEFG, Pascal M. Dohmen1DFG, Fabrizio D'Ascenzo17ABCDEFG, Abhishek J. Deshmukh18ABCDEFG, Giuseppe Biondi-Zoccai1920ABCDEFG, Hugh Calkins21DE, Gregg W. Stone22DE, Integrated Meta-Analysis of Cardiac Surgery and Cardiology-Group [IMCSC-Group]

DOI: 10.12659/MSMBR.902557

Med Sci Monit Basic Res 2017; 23:58-86

Abstract

BACKGROUND: This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of platelet cellular and functional characteristics including platelet count (PC), MPV, platelet distribution width (PDW), platelet factor 4, beta thromboglobulin (BTG), and p-selectin with the occurrence of atrial fibrillation (AF) and consequent stroke.

MATERIAL AND METHODS: We conducted a meta-analysis of observational studies evaluating platelet characteristics in patients with paroxysmal, persistent and permanent atrial fibrillations. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity.

RESULTS: Literature search of all major databases retrieved 1,676 studies. After screening, a total of 73 studies were identified. Pooled analysis showed significant differences in PC (weighted mean difference (WMD)=–26.93 and p<0.001), MPV (WMD=0.61 and p<0.001), PDW (WMD=–0.22 and p=0.002), BTG (WMD=24.69 and p<0.001), PF4 (WMD=4.59 and p<0.001), and p-selectin (WMD=4.90 and p<0.001).

CONCLUSIONS: Platelets play a critical and precipitating role in the occurrence of AF. Whereas distribution width of platelets as well as factors of platelet activity was significantly greater in AF patients compared to SR patients, platelet count was significantly lower in AF patients.

Keywords: Atrial Fibrillation, Blood Coagulation, Platelet Count

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416