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Role of Calcium/Creatinine Ratio in Urine Compared with Proteinuria and Uric Acid in Predicting Preeclampsia: A Study from Kosovo

Lindita Ibrahimi, Myrvete Paçarada, Syheda Latifi Hoxha, Astrit Bimbashi, Vlora Ademi Ibishi

Department of Gynecology, University Clinical Center of Kosovo, Medical Faculty, University of Prishtine, Prishtina, Kosovo

Med Sci Monit Basic Res 2021; 27:e929845

DOI: 10.12659/MSMBR.929845

Available online: 2021-03-01

Published: 2021-03-01


#929845

BACKGROUND: Preeclampsia is a common complication of pregnancy and a major cause of morbidity and mortality of mothers and babies worldwide. This study aimed to explore what the role of calcium/creatinine ratio is in urine compared with proteinuria and uric acid in predicting preeclampsia.
MATERIAL AND METHODS: In this prospective case-control study, 200 pregnant women who participated in the study were consecutively divided into 3 groups: a group of 59 women with preeclampsia, 61 women with pregnancy-induced hypertension, and a control group of 80 normotensive pregnant women. A 24-h urine sample was collected for estimation of calcium/creatinine ratio and proteinuria and a blood sample for estimation of uric acid at a gestational age of 24-34 weeks of pregnancy.
RESULTS: The study found that the sensitivity of proteinuria as a predictor of preeclampsia was 96.6% (P=0.000) and specificity was 21.3%. The sensitivity of uric acid as a predictor was 96.6% (P=0.000) and the specificity was 48.8%; whereas for the 24-h urine calcium/creatinine ratio, the sensitivity was 87.9% (P=0.000) and the specificity 40.7%, which corresponds to a value of 0.105 (cutoff). Women with a calcium/creatinine ratio <0.105 have a higher risk of developing preeclampsia (87.9% confidence interval, P=0.000).
CONCLUSIONS: The role of the calcium/creatinine ratio in urine is inferior to proteinuria and uric acid in predicting preeclampsia.

Keywords: Pre-Eclampsia, Proteinuria, Uric Acid



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