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24 May 2021: Meta-Analysis

Relationship of Programmed Death-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) Polymorphisms with Overall Cancer Susceptibility: An Updated Meta-Analysis of 28 Studies with 60 612 Subjects

Wenjing Zhang 12BCDEF , Yuxuan Song 34ABEF* , Xiangcheng Zhang 1ACEG*

DOI: 10.12659/MSM.932146

Med Sci Monit 2021; 27:e932146

Table 3 Meta-analyses on PD-1 and PD-L1 variants and cancer susceptibility.

GenotypeContrast modelOR (95%I)PTest for heterogeneityAnalysis model
I2 (%)P
rs10204525A vs G1.002 (0.889–1.129)0.97667.500.009R
GA vs GG1.073 (0.866–1.331)0.51749.000.081R
AA vs GG1.097 (0.817–1.474)0.53968.300.008R
AA+GA vs GG1.068 (0.843–1.354)0.58661.800.023R
AA vs AG+GG0.995 (0.856–1.599)0.94359.400.031R
rs11568821G vs A1.314 (1.116–1.547)0.0010.000.869F
AG vs AA0.911 (0.437–1.898)0.8030.000.716F
GG vs AA1.298 (0.644–2.618)0.4660.000.691F
GG+GA vs AA1.221 (0.606–2.459)0.5760.000.698F
GG vs GA+AA1.061 (0.955–1.180)0.2700.001.000F
rs17718883C vs G14.156 (4.024–49.805)85.100.001R
GC vs GG2.077 (0.645–6.691)0.2210.000.626F
CC vs GG25.488 (8.494–76.481)0.000.829F
CC+CG vs GG16.615 (5.565–49.609)0.000.855F
CC vs CG+GG16.361 (4.203–63.685)84.600.001R
rs2227981C vs T1.077 (0.753–1.539)0.68696.20R
TC vs TT1.056 (0.542–2.058)0.87394.60R
CC vs TT1.095 (0.531–2.260)0.80595.20R
CC+CT vs TT1.085 (0.548–2.146)0.81595.50R
CC vs CT+TT1.050 (0.754–1.464)0.77191.60R
rs2227982C vs T0.981 (0.898–1.071)0.66556.000.015R
TC vs TT1.050 (0.952–1.158)0.3300.000.773F
CC vs TT0.977 (0.824–1.157)0.78750.200.034R
CC+CT vs TT)1.028 (0.938–1.127)0.5550.000.498F
CC vs CT+TT0.942 (0.809–1.096)0.43764.300.003R
rs2890658A vs C1.002 (0.718–1.400)0.98979.80R
CA vs CC1.154 (0.902–1.476)0.2540.000.933F
AA vs CC1.121 (0.696–1.806)0.6380.000.542F
AA+AC vs CC1.159 (0.915–1.469)0.2200.000.640F
AA vs AC+CC1.002 (0.662–1.515)0.99476.900.001R
rs36084323G vs A0.930 (0.851–1.016)0.10649.800.036R
AG vs AA0.933 (0.842–1.034)0.18931.300.158F
GG vs AA0.829 (0.701–0.981)0.02938.800.099R
GG+GA vs AA0.903 (0.819–0.995)0.03835.100.127F
GG vs GA+AA0.913 (0.798–1.044)0.18349.000.039R
rs4143815C vs G0.752 (0.555–1.019)0.06686.90R
GC vs GG0.560 (0.365–0.860)0.00876.000.001R
CC vs GG0.537 (0.315–0.918)0.02382.00R
CC+CG vs GG0.555 (0.351–0.877)0.01281.50R
CC vs CG+GG0.809 (0.575–1.138)0.22375.700.001R
rs7421861T vsC0.980 (0.855–1.124)0.77774.20R
TC vsCC1.202 (1.031–1.402)0.0190.000.963F
TT vs CC1.171 (0.969–1.416)0.10219.800.272F
TT+CT vs CC1.181 (1.020–1.368)0.0260.000.642F
TT vs CT+CC0.947 (0.811–1.106)0.49268.100.003R

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416